Your browser doesn't support javascript.
loading
Asymmetries and Symmetries in the Mouse Oocyte and Zygote.
Chaigne, Agathe; Terret, Marie-Emilie; Verlhac, Marie-Hélène.
Affiliation
  • Chaigne A; MRC Laboratory for Molecular Cell Biology, UCL, London, WC1E 6BT, UK.
  • Terret ME; Institute for the Physics of Living Systems, UCL, London, WC1E 6BT, UK.
  • Verlhac MH; CIRB, Collège de France, CNRS-UMR7241, INSERM-U1050, Paris, 75005, France.
Results Probl Cell Differ ; 61: 285-299, 2017.
Article de En | MEDLINE | ID: mdl-28409310
Mammalian oocytes grow periodically after puberty thanks to the dialogue with their niche in the follicle. This communication between somatic and germ cells promotes the accumulation, inside the oocyte, of maternal RNAs, proteins and other molecules that will sustain the two gamete divisions and early embryo development up to its implantation. In order to preserve their stock of maternal products, oocytes from all species divide twice minimizing the volume of their daughter cells to their own benefit. For this, they undergo asymmetric divisions in size where one main objective is to locate the division spindle with its chromosomes off-centred. In this chapter, we will review how this main objective is reached with an emphasis on the role of actin microfilaments in this process in mouse oocytes, the most studied example in mammals. This chapter is subdivided into three parts: I-General features of asymmetric divisions in mouse oocytes, II-Mechanism of chromosome positioning by actin in mouse oocytes and III-Switch from asymmetric to symmetric division at the oocyte-to-embryo transition.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Ovocytes / Ovogenèse / Cytosquelette d'actine / Division cellulaire asymétrique / Souris Limites: Animals Langue: En Journal: Results Probl Cell Differ Année: 2017 Type de document: Article Pays de publication: Allemagne

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Ovocytes / Ovogenèse / Cytosquelette d'actine / Division cellulaire asymétrique / Souris Limites: Animals Langue: En Journal: Results Probl Cell Differ Année: 2017 Type de document: Article Pays de publication: Allemagne