Synthesis of 4-Halo-3(2H)-furanones Using Intramolecular Cyclization of Sulfonium Salts.

Inagaki, Sho; Nakazato, Maiko; Fukuda, Nozomi; Tamura, Satoru; Kawano, Tomikazu

Inagaki, Sho; Nakazato, Maiko; Fukuda, Nozomi; Tamura, Satoru; Kawano, Tomikazu.

Affiliation

Inagaki S; Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.
Nakazato M; Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.
Fukuda N; Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.
Tamura S; Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.
Kawano T; Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.

J Org Chem ; 82(11): 5583-5589, 2017 06 02.

Article de En | MEDLINE | ID: mdl-28493722

ABSTRACT

ABSTRACT

A simple and efficient synthesis of 4-halo-3(2H)-furanones by halogenative intramolecular cyclization of sulfonium salts is described, which can expedite the production of a variety of 4-bromo- or 4-iodo-3(2H)-furanones, useful synthetic building blocks, in good to high yield under mild conditions.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: J Org Chem Année: 2017 Type de document: Article Pays d'affiliation: Japon

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