Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome.
Pflugers Arch
; 469(7-8): 907-916, 2017 Aug.
Article
de En
| MEDLINE
| ID: mdl-28497274
ABSTRACT
Megalin (or LRP2) is an endocytic receptor that plays a central role in embryonic development and adult tissue homeostasis. Loss of this receptor in congenital or acquired diseases results in multiple organ dysfunctions, including forebrain malformation (holoprosencephaly) and renal reabsorption defects (renal Fanconi syndrome). Here, we describe current concepts of the mode of receptor action that include co-receptors and a repertoire of different ligands, and we discuss how these interactions govern functional integrity of the kidney and the brain, and cause disease when defective.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Holoprosencéphalie
/
Protéine-2 apparentée au récepteur des LDL
/
Syndrome de Fanconi
Limites:
Animals
/
Humans
Langue:
En
Journal:
Pflugers Arch
Année:
2017
Type de document:
Article
Pays d'affiliation:
Allemagne