Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.

Song, Gaojie; Yang, Dehua; Wang, Yuxia; de Graaf, Chris; Zhou, Qingtong; Jiang, Shanshan; Liu, Kaiwen; Cai, Xiaoqing; Dai, Antao; Lin, Guangyao; Liu, Dongsheng; Wu, Fan; Wu, Yiran; Zhao, Suwen; Ye, Li; Han, Gye Won; Lau, Jesper; Wu, Beili; Hanson, Michael A; Liu, Zhi-Jie; Wang, Ming-Wei; Stevens, Raymond C

Song, Gaojie; Yang, Dehua; Wang, Yuxia; de Graaf, Chris; Zhou, Qingtong; Jiang, Shanshan; Liu, Kaiwen; Cai, Xiaoqing; Dai, Antao; Lin, Guangyao; Liu, Dongsheng; Wu, Fan; Wu, Yiran; Zhao, Suwen; Ye, Li; Han, Gye Won; Lau, Jesper; Wu, Beili; Hanson, Michael A; Liu, Zhi-Jie; Wang, Ming-Wei; Stevens, Raymond C.

Affiliation

Song G; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
Yang D; The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai 201203, China.
Wang Y; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
de Graaf C; Division of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
Zhou Q; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
Jiang S; School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, China.
Liu K; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
Cai X; School of Life Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
Dai A; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.
Lin G; The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai 201203, China.
Liu D; The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai 201203, China.
Wu F; School of Life Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
Wu Y; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
Zhao S; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
Ye L; School of Life Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
Han GW; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.
Lau J; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
Wu B; iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
Hanson MA; School of Life Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China.
Liu ZJ; School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, China.
Wang MW; Department of Chemistry, Bridge Institute, University of Southern California, 3430 S. Vermont Avenue, Los Angeles, California 90089, USA.
Stevens RC; Novo Nordisk, Måløv DK-2760, Denmark.

Nature ; 546(7657): 312-315, 2017 06 08.

Article de En | MEDLINE | ID: mdl-28514449

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Récepteur du peptide-1 similaire au glucagon Limites: Humans Langue: En Journal: Nature Année: 2017 Type de document: Article Pays d'affiliation: Chine Pays de publication: Royaume-Uni

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