Helically Chiral 1-Sulfur-Functionalized [6]Helicene: Synthesis, Optical Resolution, and Functionalization.

Tsujihara, Tetsuya; Zhou, Da-Yang; Suzuki, Takeyuki; Tamura, Satoru; Kawano, Tomikazu

Tsujihara, Tetsuya; Zhou, Da-Yang; Suzuki, Takeyuki; Tamura, Satoru; Kawano, Tomikazu.

Affiliation

Tsujihara T; Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.
Zhou DY; Comprehensive Analysis Center, Institute of Scientific and Industrial Research, Osaka University , Mihogaoka, Ibaraki 567-0047, Japan.
Suzuki T; Comprehensive Analysis Center, Institute of Scientific and Industrial Research, Osaka University , Mihogaoka, Ibaraki 567-0047, Japan.
Tamura S; Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.
Kawano T; Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.

Org Lett ; 19(12): 3311-3314, 2017 06 16.

Article de En | MEDLINE | ID: mdl-28590763

ABSTRACT

ABSTRACT

The synthesis and optical resolution of helically chiral 5,6,9,10-tetrahydro-1-[6]helicenethiol and its subsequent transformations to enantiopure 1-sulfur-functionalized [6]helicenes are reported. A novel enantiopure [7]thiahelicene having a thiophene ring at the terminal position of the [6]helicene skeleton was synthesized.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: Org Lett Sujet du journal: BIOQUIMICA Année: 2017 Type de document: Article Pays d'affiliation: Japon

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