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Microbial antioxidant defense enzymes.
Staerck, Cindy; Gastebois, Amandine; Vandeputte, Patrick; Calenda, Alphonse; Larcher, Gérald; Gillmann, Louiza; Papon, Nicolas; Bouchara, Jean-Philippe; Fleury, Maxime J J.
Affiliation
  • Staerck C; Groupe d'Etude des Interactions Hôte-Pathogène (EA 3142), UNIV. Angers, UNIV. Brest, Université Bretagne - Loire, Angers, France.
  • Gastebois A; Groupe d'Etude des Interactions Hôte-Pathogène (EA 3142), UNIV. Angers, UNIV. Brest, Université Bretagne - Loire, Angers, France.
  • Vandeputte P; Groupe d'Etude des Interactions Hôte-Pathogène (EA 3142), UNIV. Angers, UNIV. Brest, Université Bretagne - Loire, Angers, France; Laboratoire de Parasitologie Mycologie, Centre Hospitalier Universitaire, Angers, France.
  • Calenda A; Groupe d'Etude des Interactions Hôte-Pathogène (EA 3142), UNIV. Angers, UNIV. Brest, Université Bretagne - Loire, Angers, France.
  • Larcher G; Groupe d'Etude des Interactions Hôte-Pathogène (EA 3142), UNIV. Angers, UNIV. Brest, Université Bretagne - Loire, Angers, France.
  • Gillmann L; Groupe d'Etude des Interactions Hôte-Pathogène (EA 3142), UNIV. Angers, UNIV. Brest, Université Bretagne - Loire, Angers, France.
  • Papon N; Groupe d'Etude des Interactions Hôte-Pathogène (EA 3142), UNIV. Angers, UNIV. Brest, Université Bretagne - Loire, Angers, France.
  • Bouchara JP; Groupe d'Etude des Interactions Hôte-Pathogène (EA 3142), UNIV. Angers, UNIV. Brest, Université Bretagne - Loire, Angers, France; Laboratoire de Parasitologie Mycologie, Centre Hospitalier Universitaire, Angers, France.
  • Fleury MJJ; Groupe d'Etude des Interactions Hôte-Pathogène (EA 3142), UNIV. Angers, UNIV. Brest, Université Bretagne - Loire, Angers, France. Electronic address: maxime.fleury@univ-angers.fr.
Microb Pathog ; 110: 56-65, 2017 Sep.
Article de En | MEDLINE | ID: mdl-28629723
ABSTRACT
Free radicals are often described as chemical compounds characterized by unpaired electrons in their outer orbital rendering them highly reactive species. In mammalians, studies on free radicals were focused on reactive oxygen species (ROS) or reactive nitrogen species (RNS) due to their relative importance in physiological as well as in pathological processes. These cellular compounds are produced by different physiological systems such as the aerobic metabolism and play a major role in cell signaling pathways but also in the host immune defenses against pathogenic microorganisms. ROS and RNS are highly reactive species with potentially harmful effects on any cellular components (lipids, proteins and nucleic acids) when produced with a high level. To maintain ROS and RNS at a non-toxic concentration, enzymatic and non-enzymatic cellular antioxidants coordinate the balance between their production and their degradation. Superoxide dismutases, catalases, glutathione system, thioredoxin system, peroxidase systems, flavohemoglobins and nitrate or nitrite reductases represent the prominent enzymatic antioxidants used to scavenge excess of internal as well as external ROS and RNS. Bacteria, fungi and parasites also display similar enzymatic activities to escape the host oxidative defenses during the immune response against infectious processes. Here we summarize current knowledge on the enzymatic systems that allow microorganisms to fight against ROS and RNS, and shed light on the role that take some of them in microbial infections. Such microbial protective systems are considered as virulence factors, and therefore represent key targets for diagnosis of the infections or development of anti-infectious drugs.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Parasites / Espèces réactives de l'oxygène / Espèces réactives de l'azote / Phénomènes microbiologiques / Antioxydants Limites: Animals / Humans Langue: En Journal: Microb Pathog Sujet du journal: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Année: 2017 Type de document: Article Pays d'affiliation: France

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Parasites / Espèces réactives de l'oxygène / Espèces réactives de l'azote / Phénomènes microbiologiques / Antioxydants Limites: Animals / Humans Langue: En Journal: Microb Pathog Sujet du journal: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Année: 2017 Type de document: Article Pays d'affiliation: France