Evaluation of anti-inflammatory and anti-oxidant potential of seed extracts of Vernonia anthelmintica.
Pak J Pharm Sci
; 30(3): 755-760, 2017 May.
Article
de En
| MEDLINE
| ID: mdl-28653918
ABSTRACT
Seeds of Vernonia anthelmintica in the form of Ethanol seed extract of Vernonia anthelmintica (EEVA), Hexane extract of Vernonia anthelmintica (HEVA) and water decoction of Vernonia anthelmintica (WDVA) were evaluated for their in-vivo anti-Inflammatory potential in carrageenan induced rat paw model. The results were compared to anti-inflammatory activity of standard drug (ibuprofen) and untreated groups. In-vitro evaluation of antioxidant potential of EEVA and HEVA were also conducted by "DPPH scavenging assay". The results of present study depicts that HEVA and EEVA in higher dose possess a strong anti-inflammatory potential as compared to standard anti-inflammatory drugs, whereas WDVA showed milder anti-inflammatory potential. DPPH assay has revealed strong anti-oxidant potential of EEVC with the percentage Radical Scavenging activity (%RSA) of 89.709 at concentrations of 500 ul as compared to standard drugs gallic acid (23.436±0.43) and acetyl salicylic acid (111.44±0.7) at concentrations of 95.95 µM. The other extract HEVC has shown to have insignificant %RSA at the concentration of 500µl. Hence the present study revealed that selected extracts of Vernonia anthelmintica exhibited significant in-vitro antioxidant and in-vivo anti-inflammatory potential.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Graines
/
Extraits de plantes
/
Vernonia
/
Anti-inflammatoires
/
Antioxydants
Limites:
Animals
Langue:
En
Journal:
Pak J Pharm Sci
Sujet du journal:
FARMACIA
/
FARMACOLOGIA
/
QUIMICA
Année:
2017
Type de document:
Article
Pays d'affiliation:
Pakistan