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Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.
Trifirò, Paolo; Cappa, Anna; Brambillasca, Silvia; Botrugno, Oronza A; Cera, Maria Rosaria; Zuffo, Roberto Dal; Dessanti, Paola; Meroni, Giuseppe; Thaler, Florian; Villa, Manuela; Minucci, Saverio; Mercurio, Ciro; Varasi, Mario; Vianello, Paola.
Affiliation
  • Trifirò P; Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.
  • Cappa A; Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.
  • Brambillasca S; Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.
  • Botrugno OA; Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.
  • Cera MR; Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.
  • Zuffo RD; Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.
  • Dessanti P; Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.
  • Meroni G; Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.
  • Thaler F; Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.
  • Villa M; Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.
  • Minucci S; Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.
  • Mercurio C; Department of Biosciences, University of Milan, Via Celoria, 26, 20133 Milan, Italy.
  • Varasi M; Department of Experimental Oncology, Academic Drug Discovery, European Institute of Oncology, Ifom-IEO-Campus, via Adamello 16, 20139 Milan, Italy.
  • Vianello P; Genextra Group, DAC s.r.l., Via Adamello 16, 20139 Milan, Italy.
Future Med Chem ; 9(11): 1161-1174, 2017 07.
Article de En | MEDLINE | ID: mdl-28722470
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tranylcypromine / Leucémie aiguë promyélocytaire / Histone Demethylases / Antinéoplasiques Limites: Animals / Humans Langue: En Journal: Future Med Chem Année: 2017 Type de document: Article Pays d'affiliation: Italie Pays de publication: Royaume-Uni
Texte intégral
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XML
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tranylcypromine / Leucémie aiguë promyélocytaire / Histone Demethylases / Antinéoplasiques Limites: Animals / Humans Langue: En Journal: Future Med Chem Année: 2017 Type de document: Article Pays d'affiliation: Italie Pays de publication: Royaume-Uni