A novel splice site mutation of myosin VI in mice leads to stereociliary fusion caused by disruption of actin networks in the apical region of inner ear hair cells.

Seki, Yuta; Miyasaka, Yuki; Suzuki, Sari; Wada, Kenta; Yasuda, Shumpei P; Matsuoka, Kunie; Ohshiba, Yasuhiro; Endo, Kentaro; Ishii, Rie; Shitara, Hiroshi; Kitajiri, Shin-Ichiro; Nakagata, Naomi; Takebayashi, Hirohide; Kikkawa, Yoshiaki

Seki, Yuta; Miyasaka, Yuki; Suzuki, Sari; Wada, Kenta; Yasuda, Shumpei P; Matsuoka, Kunie; Ohshiba, Yasuhiro; Endo, Kentaro; Ishii, Rie; Shitara, Hiroshi; Kitajiri, Shin-Ichiro; Nakagata, Naomi; Takebayashi, Hirohide; Kikkawa, Yoshiaki.

Affiliation

Seki Y; Mammalian Genetics Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Miyasaka Y; Mammalian Genetics Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Suzuki S; Division of Experimental Animals, Center for Promotion of Medical Research and Education, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan.
Wada K; Mammalian Genetics Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Yasuda SP; Mammalian Genetics Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Matsuoka K; Laboratory of Animal Biotechnology, Department of Bioproduction, Faculty of Bioindustry, Tokyo University of Agriculture, Abashiri, Hokkaido, Japan.
Ohshiba Y; Mammalian Genetics Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Endo K; Mammalian Genetics Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Ishii R; Mammalian Genetics Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Shitara H; Histology Laboratory, Advanced Technical Support Department, Center for Basic Technology Research, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Kitajiri SI; Laboratory for Transgenic Technology, Animal Research Division, Center for Basic Technology Research, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Nakagata N; Laboratory for Transgenic Technology, Animal Research Division, Center for Basic Technology Research, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Takebayashi H; Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kikkawa Y; Division of Reproductive Engineering, Center for Animal Resources and Development (CARD), Kumamoto University, Kumamoto, Japan.

PLoS One ; 12(8): e0183477, 2017.

Article de En | MEDLINE | ID: mdl-28832620

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Actines / Épissage alternatif / Chaînes lourdes de myosine / Cellules ciliées auditives internes / Mutation Limites: Animals Langue: En Journal: PLoS One Sujet du journal: CIENCIA / MEDICINA Année: 2017 Type de document: Article Pays d'affiliation: Japon

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