Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma.
PLoS Genet
; 13(8): e1006879, 2017 Aug.
Article
de En
| MEDLINE
| ID: mdl-28859074
ABSTRACT
Oesophageal adenocarcinoma (OAC) is one of the ten most prevalent forms of cancer and is showing a rapid increase in incidence and yet exhibits poor survival rates. Compared to many other common cancers, the molecular changes that occur in this disease are relatively poorly understood. However, genes encoding chromatin remodeling enzymes are frequently mutated in OAC. This is consistent with the emerging concept that cancer cells exhibit reprogramming of their chromatin environment which leads to subsequent changes in their transcriptional profile. Here, we have used ATAC-seq to interrogate the chromatin changes that occur in OAC using both cell lines and patient-derived material. We demonstrate that there are substantial changes in the regulatory chromatin environment in the cancer cells and using this data we have uncovered an important role for ETS and AP1 transcription factors in driving the changes in gene expression found in OAC cells.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Facteurs de transcription
/
Tumeurs de l'oesophage
/
Adénocarcinome
/
Protéines proto-oncogènes
/
Protéines E1A d'adénovirus
/
Facteur de transcription AP-1
/
Protéines de liaison à l'ADN
Type d'étude:
Prognostic_studies
Limites:
Humans
Langue:
En
Journal:
PLoS Genet
Sujet du journal:
GENETICA
Année:
2017
Type de document:
Article
Pays d'affiliation:
Royaume-Uni