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Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.
Pippione, Agnese C; Giraudo, Alessandro; Bonanni, Davide; Carnovale, Irene M; Marini, Elisabetta; Cena, Clara; Costale, Annalisa; Zonari, Daniele; Pors, Klaus; Sadiq, Maria; Boschi, Donatella; Oliaro-Bosso, Simonetta; Lolli, Marco L.
Affiliation
  • Pippione AC; Department of Science and Drug Technology, University of Torino, Via Pietro Giuria 9, 10125 Torino, Italy.
  • Giraudo A; Department of Science and Drug Technology, University of Torino, Via Pietro Giuria 9, 10125 Torino, Italy.
  • Bonanni D; Department of Science and Drug Technology, University of Torino, Via Pietro Giuria 9, 10125 Torino, Italy.
  • Carnovale IM; Department of Science and Drug Technology, University of Torino, Via Pietro Giuria 9, 10125 Torino, Italy.
  • Marini E; Department of Science and Drug Technology, University of Torino, Via Pietro Giuria 9, 10125 Torino, Italy.
  • Cena C; Department of Science and Drug Technology, University of Torino, Via Pietro Giuria 9, 10125 Torino, Italy.
  • Costale A; Department of Science and Drug Technology, University of Torino, Via Pietro Giuria 9, 10125 Torino, Italy.
  • Zonari D; Department of Science and Drug Technology, University of Torino, Via Pietro Giuria 9, 10125 Torino, Italy.
  • Pors K; Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, West Yorkshire BD7 1DP, UK.
  • Sadiq M; Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, West Yorkshire BD7 1DP, UK.
  • Boschi D; Department of Science and Drug Technology, University of Torino, Via Pietro Giuria 9, 10125 Torino, Italy.
  • Oliaro-Bosso S; Department of Science and Drug Technology, University of Torino, Via Pietro Giuria 9, 10125 Torino, Italy. Electronic address: simona.oliaro@unito.it.
  • Lolli ML; Department of Science and Drug Technology, University of Torino, Via Pietro Giuria 9, 10125 Torino, Italy. Electronic address: marco.lolli@unito.it.
Eur J Med Chem ; 139: 936-946, 2017 Oct 20.
Article de En | MEDLINE | ID: mdl-28881288
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Triazoles / Hydroxyprostaglandine dehydrogenases / Antienzymes / 3-Hydroxysteroid dehydrogenases Limites: Humans Langue: En Journal: Eur J Med Chem Année: 2017 Type de document: Article Pays d'affiliation: Italie
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Triazoles / Hydroxyprostaglandine dehydrogenases / Antienzymes / 3-Hydroxysteroid dehydrogenases Limites: Humans Langue: En Journal: Eur J Med Chem Année: 2017 Type de document: Article Pays d'affiliation: Italie