A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study.

Su, Chong; Sun, Hui; Yang, Hong; Yin, Lei; Zhang, Jiwen; Fawcett, John Paul; Gu, Jingkai

Su, Chong; Sun, Hui; Yang, Hong; Yin, Lei; Zhang, Jiwen; Fawcett, John Paul; Gu, Jingkai.

Affiliation

Su C; School of Life Sciences, Jilin University, No. 2699 Qinajin Road, Changchun, Jilin, 130012, China.
Sun H; School of Life Sciences, Jilin University, No. 2699 Qinajin Road, Changchun, Jilin, 130012, China.
Yang H; School of Life Sciences, Jilin University, No. 2699 Qinajin Road, Changchun, Jilin, 130012, China.
Yin L; School of Life Sciences, Jilin University, No. 2699 Qinajin Road, Changchun, Jilin, 130012, China.
Zhang J; Center for Drug Delivery System, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Fawcett JP; School of Pharmacy, University of Otago, P.O. Box 56, Dunedin, 9054, New Zealand.
Gu J; School of Life Sciences, Jilin University, No. 2699 Qinajin Road, Changchun, Jilin, 130012, China. gujk@jlu.edu.cn.

Anal Bioanal Chem ; 409(28): 6559-6565, 2017 Nov.

Article de En | MEDLINE | ID: mdl-28889219

Sujet(s)
Mots clés

Ion exchange solid phase extraction; LC-MS/MS; Porcine relaxin; Ultrahigh performance liquid chromatography

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Relaxine / Chromatographie en phase liquide à haute performance / Spectrométrie de masse en tandem / Extraction en phase solide Limites: Animals Langue: En Journal: Anal Bioanal Chem Année: 2017 Type de document: Article Pays d'affiliation: Chine Pays de publication: Allemagne

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