Signaling by Small GTPases at Cell-Cell Junctions: Protein Interactions Building Control and Networks.
Cold Spring Harb Perspect Biol
; 10(10)2018 10 01.
Article
de En
| MEDLINE
| ID: mdl-28893858
ABSTRACT
A number of interesting reports highlight the intricate network of signaling proteins that coordinate formation and maintenance of cell-cell contacts. We have much yet to learn about how the in vitro binding data is translated into protein association inside the cells and whether such interaction modulates the signaling properties of the protein. What emerges from recent studies is the importance to carefully consider small GTPase activation in the context of where its activation occurs, which upstream regulators are involved in the activation/inactivation cycle and the GTPase interacting partners that determine the intracellular niche and extent of signaling. Data discussed here unravel unparalleled cooperation and coordination of functions among GTPases and their regulators in supporting strong adhesion between cells.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protéines du cytosquelette
/
DGTPases
/
Jonctions intercellulaires
Limites:
Animals
/
Humans
Langue:
En
Journal:
Cold Spring Harb Perspect Biol
Sujet du journal:
BIOLOGIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
Royaume-Uni