An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model.

Patel, Ami; DiGiandomenico, Antonio; Keller, Ashley E; Smith, Trevor R F; Park, Daniel H; Ramos, Stephanie; Schultheis, Katherine; Elliott, Sarah T C; Mendoza, Janess; Broderick, Kate E; Wise, Megan C; Yan, Jian; Jiang, Jingjing; Flingai, Seleeke; Khan, Amir S; Muthumani, Kar; Humeau, Laurent; Cheng, Lily I; Wachter-Rosati, Leslie; Stover, C Kendall; Sardesai, Niranjan Y; Weiner, David B

Patel, Ami; DiGiandomenico, Antonio; Keller, Ashley E; Smith, Trevor R F; Park, Daniel H; Ramos, Stephanie; Schultheis, Katherine; Elliott, Sarah T C; Mendoza, Janess; Broderick, Kate E; Wise, Megan C; Yan, Jian; Jiang, Jingjing; Flingai, Seleeke; Khan, Amir S; Muthumani, Kar; Humeau, Laurent; Cheng, Lily I; Wachter-Rosati, Leslie; Stover, C Kendall; Sardesai, Niranjan Y; Weiner, David B.

Affiliation

Patel A; The Wistar Institute of Anatomy & Biology, Philadelphia, PA, 19104, USA.
DiGiandomenico A; MedImmune, Gaithersburg, MD, 20878, USA.
Keller AE; MedImmune, Gaithersburg, MD, 20878, USA.
Smith TRF; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
Park DH; The Wistar Institute of Anatomy & Biology, Philadelphia, PA, 19104, USA.
Ramos S; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
Schultheis K; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
Elliott STC; The Wistar Institute of Anatomy & Biology, Philadelphia, PA, 19104, USA.
Mendoza J; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
Broderick KE; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
Wise MC; The Wistar Institute of Anatomy & Biology, Philadelphia, PA, 19104, USA.
Yan J; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
Jiang J; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
Flingai S; The Wistar Institute of Anatomy & Biology, Philadelphia, PA, 19104, USA.
Khan AS; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
Muthumani K; The Wistar Institute of Anatomy & Biology, Philadelphia, PA, 19104, USA.
Humeau L; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
Cheng LI; MedImmune, Gaithersburg, MD, 20878, USA.
Wachter-Rosati L; MedImmune, Gaithersburg, MD, 20878, USA.
Stover CK; MedImmune, Gaithersburg, MD, 20878, USA.
Sardesai NY; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA.
Weiner DB; The Wistar Institute of Anatomy & Biology, Philadelphia, PA, 19104, USA. dweiner@wistar.org.

Nat Commun ; 8(1): 637, 2017 09 21.

Article de En | MEDLINE | ID: mdl-28935938

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pseudomonas aeruginosa / Immunoglobuline G / Ingénierie des protéines / Anticorps bispécifiques / Pneumopathie bactérienne / Anticorps antibactériens Limites: Animals / Humans Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2017 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Royaume-Uni

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