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Influence of body composition on disposition of the highly fat distributed compound as analysed by physiologically based pharmacokinetic (PBPK) modeling and simulation.
Goto, Akihiko; Tagawa, Yoshihiko; Moriya, Yuu; Sato, Sho; Yamamoto, Masami; Wakabayashi, Takeshi; Tsukamoto, Tetsuya; DeJongh, Joost; van Steeg, Tamara J; Moriwaki, Toshiya; Asahi, Satoru.
Affiliation
  • Goto A; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co. Ltd, Kanagawa, Japan.
  • Tagawa Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co. Ltd, Kanagawa, Japan.
  • Moriya Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co. Ltd, Kanagawa, Japan.
  • Sato S; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co. Ltd, Kanagawa, Japan.
  • Yamamoto M; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co. Ltd, Kanagawa, Japan.
  • Wakabayashi T; Central Nervous System Drug Discovery Unit, Takeda Pharmaceutical Co. Ltd, Kanagawa, Japan.
  • Tsukamoto T; Inflammation Drug Discovery Unit Takeda Pharmaceutical Co. Ltd, Kanagawa, Japan.
  • DeJongh J; Leiden Advanced Pharmacokinetics & Pharmacodynamics (LAP&P) Consultants, Leiden, The Netherlands.
  • van Steeg TJ; Leiden Advanced Pharmacokinetics & Pharmacodynamics (LAP&P) Consultants, Leiden, The Netherlands.
  • Moriwaki T; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co. Ltd, Kanagawa, Japan.
  • Asahi S; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Co. Ltd, Kanagawa, Japan.
Biopharm Drug Dispos ; 38(9): 543-552, 2017 Dec.
Article de En | MEDLINE | ID: mdl-28948605
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pipérazines / Benzofuranes / Tissu adipeux / Lipides / Modèles biologiques Type d'étude: Prognostic_studies Limites: Animals Langue: En Journal: Biopharm Drug Dispos Année: 2017 Type de document: Article Pays d'affiliation: Japon
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pipérazines / Benzofuranes / Tissu adipeux / Lipides / Modèles biologiques Type d'étude: Prognostic_studies Limites: Animals Langue: En Journal: Biopharm Drug Dispos Année: 2017 Type de document: Article Pays d'affiliation: Japon