Synthesis of monoalkylidene diketopiperazines and application to the synthesis of barettin.
Org Biomol Chem
; 15(40): 8634-8640, 2017 Oct 18.
Article
de En
| MEDLINE
| ID: mdl-28980696
ABSTRACT
The synthesis of barettin, a selective serotonin receptor inhibitor and potent antibiofouling natural product, is described. The synthesis starts with the diketopiperazine nucleus intact and the side chains are installed using iterative aldol condensations. The route represents a general strategy for synthesis of a wide array of mono-alkylidene diketopiperazine structures, including those derived from non-canonical amino acid residues.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Peptides cycliques
/
Pipérazinediones
Langue:
En
Journal:
Org Biomol Chem
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2017
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique