CD44 Expression Is a Prognostic Factor in Patients with Intrahepatic Cholangiocarcinoma After Surgical Resection.
Anticancer Res
; 37(10): 5701-5705, 2017 10.
Article
de En
| MEDLINE
| ID: mdl-28982889
ABSTRACT
BACKGROUND/AIM:
Cancer stem cells (CSC) plays an important role in various kinds of cancers. The aim of this study was to clarify the role of CD44 expression in intrahepatic cholangiocarcinoma (IHCC) as a marker of CSCs. MATERIALS ANDMETHODS:
Thirty-five patients with IHCC patients who underwent hepatectomy were evaluated. CD44 expression was determined immunohistochemically. The patients were divided into a CD44-positive group (n=22) or CD44-negative group (n=13). Clinicopathological variables including prognosis were compared between the two groups.RESULTS:
The CD44-positive group had a worse prognosis than the CD44-negative group (5-year survival 19.3% vs. 55.5%, respectively, p=0.016), although no difference in the background variables was observed. In multivariate analysis, CD44-positivity was identified as an independent prognostic factor (hazard ratio=3.676, p=0.034).CONCLUSION:
These data suggest that CD44-positivity might be a candidate CSC marker in IHCC and a prognostic indicator.Mots clés
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cellules souches tumorales
/
Tumeurs des canaux biliaires
/
Marqueurs biologiques tumoraux
/
Cholangiocarcinome
/
Antigènes CD44
/
Hépatectomie
Type d'étude:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Anticancer Res
Année:
2017
Type de document:
Article
Pays d'affiliation:
Japon