Synthesis and evaluation of the inhibitory activity of the four stereoisomers of the potent and selective human Î³-glutamyl transpeptidase inhibitor GGsTop.

Watanabe, Bunta; Tabuchi, Yukiko; Wada, Kei; Hiratake, Jun

Watanabe, Bunta; Tabuchi, Yukiko; Wada, Kei; Hiratake, Jun.

Affiliation

Watanabe B; Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. Electronic address: bunta@scl.kyoto-u.ac.jp.
Tabuchi Y; Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.
Wada K; Department of Medical Sciences, University of Miyazaki, Miyazaki 889-1692, Japan.
Hiratake J; Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.

Bioorg Med Chem Lett ; 27(21): 4920-4924, 2017 11 01.

Article de En | MEDLINE | ID: mdl-28985998

Sujet(s)
Mots clés

Chiral pool synthesis; GGsTop; Mechanism-based inhibitor; Molecular modeling; Î³-Glutamyl transpeptidase

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Antienzymes / Phosphonates / Gamma-Glutamyltransferase / Amino-butyrates Limites: Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2017 Type de document: Article Pays de publication: Royaume-Uni

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