Refractory Pseudomonas Bacteremia in a 2-Year-Old Sterilized by Bacteriophage Therapy.

Duplessis, C; Biswas, B; Hanisch, B; Perkins, M; Henry, M; Quinones, J; Wolfe, D; Estrella, L; Hamilton, T

Duplessis, C; Biswas, B; Hanisch, B; Perkins, M; Henry, M; Quinones, J; Wolfe, D; Estrella, L; Hamilton, T.

Affiliation

Duplessis C; Enteric Disease Department, Infectious Disease Directorate, Naval Medical Research Center, Silver Spring, Maryland.
Biswas B; Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, Maryland.
Hanisch B; Henry M. Jackson Foundation, Bethesda, Maryland.
Perkins M; Pediatric Infectious Diseases, Children's National Medical Center, Washington, DC.
Henry M; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC.
Quinones J; Walter Reed National Military Medical Center, Bethesda, Maryland.
Wolfe D; Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, Maryland.
Estrella L; Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, Maryland.
Hamilton T; Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, Maryland.

J Pediatric Infect Dis Soc ; 7(3): 253-256, 2018 Aug 17.

Article de En | MEDLINE | ID: mdl-28992111

ABSTRACT

ABSTRACT

Here, we report a complex case that involved a pediatric patient who experienced recalcitrant multidrug-resistant Pseudomonas aeruginosa infection complicated by bacteremia/sepsis; our antibacterial options were limited because of resistance, allergies, and suboptimal source control. A cocktail of 2 bacteriophages targeting the infectious organism introduced on 2 separate occasions sterilized the bacteremia.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Infections à Pseudomonas / Bactériémie / Phagothérapie Limites: Child, preschool / Humans / Male Langue: En Journal: J Pediatric Infect Dis Soc Année: 2018 Type de document: Article

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