Rhodium(III)-Catalyzed Directed C-H Amidation of N-Nitrosoanilines and Subsequent Formation of 1,2-Disubstituted Benzimidazoles.

Chen, Yanyu; Zhang, Rong; Peng, Qiujun; Xu, Lanting; Pan, XianHua

Chen, Yanyu; Zhang, Rong; Peng, Qiujun; Xu, Lanting; Pan, XianHua.

Affiliation

Chen Y; School of Perfume and Aroma Technology, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai, 201418, P.R. China.
Zhang R; School of Perfume and Aroma Technology, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai, 201418, P.R. China.
Peng Q; School of Perfume and Aroma Technology, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai, 201418, P.R. China.
Xu L; Shanghai Research Institute of Fragrance and Flavor Industry, 480 Nanning Road, Shanghai, 200232, P.R. China.
Pan X; Shanghai Research Institute of Fragrance and Flavor Industry, 480 Nanning Road, Shanghai, 200232, P.R. China.

Chem Asian J ; 12(21): 2804-2808, 2017 Nov 02.

Article de En | MEDLINE | ID: mdl-29024502

ABSTRACT

ABSTRACT

An efficient rhodium-catalyzed direct C-H amidation of N-nitrosoanilines with 1,4,2-dioxazol-5-ones as amidating agents has been developed. This method featured mild reaction conditions, a wide substrate scope and satisfactory yields. Besides, the amidated products could be readily converted to pharmaceutically valuable 1,2-disubstituted benzimidazoles via an HCl-mediated deprotection/cyclization process in one pot.

Mots clés

C−H activation; N-nitrosoanilines; benzimidazoles; domino reactions; rhodium

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: Chem Asian J Année: 2017 Type de document: Article