Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells.
AIDS
; 31(17): 2431-2433, 2017 11 13.
Article
de En
| MEDLINE
| ID: mdl-29028655
ABSTRACT
Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Lymphocytes B
/
Anticorps anti-VIH
/
Infections à VIH
/
VIH-2 (Virus de l'Immunodéficience Humaine de type 2)
/
Anticorps neutralisants
/
Mémoire immunologique
Type d'étude:
Risk_factors_studies
Limites:
Adult
/
Humans
Langue:
En
Journal:
AIDS
Sujet du journal:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Année:
2017
Type de document:
Article