Estimation of a significance threshold for epigenome-wide association studies.

Saffari, Ayden; Silver, Matt J; Zavattari, Patrizia; Moi, Loredana; Columbano, Amedeo; Meaburn, Emma L; Dudbridge, Frank

Saffari, Ayden; Silver, Matt J; Zavattari, Patrizia; Moi, Loredana; Columbano, Amedeo; Meaburn, Emma L; Dudbridge, Frank.

Affiliation

Saffari A; Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Silver MJ; MRC Unit, The Gambia and MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Zavattari P; Department of Psychological Sciences, Birkbeck, University of London, London, United Kingdom.
Moi L; MRC Unit, The Gambia and MRC International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Columbano A; Department of Biomedical Sciences, University of Cagliari, Cagliari, Sardinia, Italy.
Meaburn EL; Department of Biomedical Sciences, University of Cagliari, Cagliari, Sardinia, Italy.
Dudbridge F; Department of Biomedical Sciences, University of Cagliari, Cagliari, Sardinia, Italy.

Genet Epidemiol ; 42(1): 20-33, 2018 02.

Article de En | MEDLINE | ID: mdl-29034560

Sujet(s)
Mots clés

CpG; DNA methylation; EWAS; FWER; GWAS; epigenetic epidemiology; permutation; resampling; simulation extrapolation

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Génome humain / Ilots CpG / Méthylation de l'ADN / Épigenèse génétique / Étude d'association pangénomique Type d'étude: Risk_factors_studies Limites: Adolescent / Adult / Aged / Aged80 / Humans / Infant / Middle aged Langue: En Journal: Genet Epidemiol Sujet du journal: EPIDEMIOLOGIA / GENETICA MEDICA Année: 2018 Type de document: Article Pays d'affiliation: Royaume-Uni

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