Modeling neurological diseases using iPSC-derived neural cells : iPSC modeling of neurological diseases.
Cell Tissue Res
; 371(1): 143-151, 2018 01.
Article
de En
| MEDLINE
| ID: mdl-29079884
ABSTRACT
Developing efficient models for neurological diseases enables us to uncover disease mechanisms and develop therapeutic strategies to treat them. Discovery of reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the way of modeling human diseases, especially neurological diseases. Currently almost all types of neural cells, including but not limited to neural stem cells, neurons, astrocytes, oligodendrocytes and microglia, can be derived from iPSCs following developmental principles. These iPSC-derived neural cells provide valuable tools for studying neurological disease mechanisms, developing potential therapies, and deepening our understanding of the nervous system.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cellules souches pluripotentes induites
/
Cellules souches neurales
/
Modèles neurologiques
/
Maladies du système nerveux
Limites:
Animals
/
Humans
Langue:
En
Journal:
Cell Tissue Res
Année:
2018
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique