Stability of Cortical Thinning in Persons at Increased Familial Risk for Major Depressive Disorder Across 8 Years.
Biol Psychiatry Cogn Neurosci Neuroimaging
; 2(7): 619-625, 2017 Oct.
Article
de En
| MEDLINE
| ID: mdl-29085917
ABSTRACT
BACKGROUND:
A biological marker of vulnerability should precede onset of illness and be independent of disease course. We previously reported that cortical thinning may serve as a potential biomarker for risk for familial depression. We now test stability of the cortical thinning across 8 years, and whether thinning mediates associations between familial risk and depressive traits.METHOD:
Participants were from a 3-generation family study of depression, where 2nd and 3rd generation offspring were characterized as being at high- or low-risk for depression based on the presence/absence of major depression in the 1st generation. The analysis includes 82 offspring with anatomical MRI scans across two assessment waves, 7.8 (S.D.1.3, range 5.2-10.9) years apart.RESULTS:
High-risk offspring had thinner bilateral superior and middle frontal gyri, and left inferior parietal lobule, at both time-points. High intra-subject correlation (0.60CONCLUSION:
The study provides evidence for cortical thinning as a stable biomarker for familial vulnerability for depressive illness, which supports the ability to detect persistent and clinically relevant anatomical findings irrespective of MRI platform.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Type d'étude:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Langue:
En
Journal:
Biol Psychiatry Cogn Neurosci Neuroimaging
Année:
2017
Type de document:
Article