Anticancer and Immunogenic Properties of Cardiac Glycosides.
Molecules
; 22(11)2017 Nov 08.
Article
de En
| MEDLINE
| ID: mdl-29117117
ABSTRACT
Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several cardiac conditions and more recently have been recognized as potential antitumor compounds. They are known to be ligands for Na/K-ATPase, which is a promising drug target in cancer. More recently, in addition to their antitumor effects, it has been suggested that CGs activate tumor-specific immune responses. This review summarizes the anticancer aspects of CGs as new strategies for immunotherapy and drug repositioning (new horizons for old players), and the possible new targets for CGs in cancer cells.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Glucosides cardiotoniques
/
Sodium-Potassium-Exchanging ATPase
/
Facteurs immunologiques
/
Tumeurs
/
Antinéoplasiques
Limites:
Animals
/
Humans
Langue:
En
Journal:
Molecules
Sujet du journal:
BIOLOGIA
Année:
2017
Type de document:
Article
Pays d'affiliation:
Brésil