A rapid and sensitive chiral LC-MS/MS method for the determination of ketamine and norketamine in mouse plasma, brain and cerebrospinal fluid applicable to the stereoselective pharmacokinetic study of ketamine.

Toki, Hidetoh; Ichikawa, Takuya; Mizuno-Yasuhira, Akiko; Yamaguchi, Jun-Ichi

Toki, Hidetoh; Ichikawa, Takuya; Mizuno-Yasuhira, Akiko; Yamaguchi, Jun-Ichi.

Affiliation

Toki H; Pharmacokinetics and Metabolism, Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Ichikawa T; Pharmacokinetics and Metabolism, Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Mizuno-Yasuhira A; Pharmacokinetics and Metabolism, Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Yamaguchi JI; Pharmacokinetics and Metabolism, Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.

J Pharm Biomed Anal ; 148: 288-297, 2018 Jan 30.

Article de En | MEDLINE | ID: mdl-29126076

Sujet(s)
Mots clés

Antidepressant; Chiral LCMS/MS; Ketamine; Mice; Norketamine; Pharmacokinetics

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Plasma sanguin / Encéphale / Liquide cérébrospinal / Kétamine Type d'étude: Diagnostic_studies Limites: Animals Langue: En Journal: J Pharm Biomed Anal Année: 2018 Type de document: Article Pays d'affiliation: Japon Pays de publication: Royaume-Uni

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