Regulatory T cells are expanded by Teriparatide treatment in humans and mediate intermittent PTH-induced bone anabolism in mice.
EMBO Rep
; 19(1): 156-171, 2018 01.
Article
de En
| MEDLINE
| ID: mdl-29158349
ABSTRACT
Teriparatide is a bone anabolic treatment for osteoporosis, modeled in animals by intermittent PTH (iPTH) administration, but the cellular and molecular mechanisms of action of iPTH are largely unknown. Here, we show that Teriparatide and iPTH cause a ~two-threefold increase in the number of regulatory T cells (Tregs) in humans and mice. Attesting in vivo relevance, blockade of the Treg increase in mice prevents the increase in bone formation and trabecular bone volume and structure induced by iPTH Therefore, increasing the number of Tregs is a pivotal mechanism by which iPTH exerts its bone anabolic activity. Increasing Tregs pharmacologically may represent a novel bone anabolic therapy, while iPTH-induced Treg increase may find applications in inflammatory conditions and transplant medicine.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Ostéoporose post-ménopausique
/
Lymphocytes T régulateurs
/
Tériparatide
/
Agents de maintien de la densité osseuse
/
Hormones et agents régulant le calcium
Type d'étude:
Prognostic_studies
Langue:
En
Journal:
EMBO Rep
Sujet du journal:
BIOLOGIA MOLECULAR
Année:
2018
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique
Pays de publication:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM