Deep brain stimulation induces antidepressant-like effects in serotonin transporter knockout mice.
Brain Stimul
; 11(2): 423-425, 2018.
Article
de En
| MEDLINE
| ID: mdl-29174865
ABSTRACT
BACKGROUND:
Some of the antidepressant-like effects of ventromedial prefrontal cortex (vmPFC) deep brain stimulation (DBS) in rodents have been attributed to the modulation of prefrontal-raphe pathways. This is largely different from selective serotonin reuptake inhibitors (SSRIs), which increase serotonin (5-HT) levels by inhibiting the serotonin transporter (SERT). SSRIs have limited efficacy when given to SERT knockout (KO) mice, or patients with mutations in the serotonin transporter promoter gene (5-HTTLPR).HYPOTHESIS:
vmPFC DBS will induce antidepressant-like effects and serotonin release in SERT KOs.RESULTS:
DBS-treated wild-type and SERT KO mice had a significant 22-26% decrease in immobility in the forced swim test. DBS delivered to either group was associated with 33-55% increase in 5-HT levels.CONCLUSIONS:
DBS induced a significant antidepressant-like effect in KO mice. This suggests that it may be reasonable to consider DBS in states where SERT is not fully operational.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Stimulation cérébrale profonde
/
Transporteurs de la sérotonine
Limites:
Animals
Langue:
En
Journal:
Brain Stimul
Sujet du journal:
CEREBRO
Année:
2018
Type de document:
Article
Pays d'affiliation:
Canada