Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures.

Zietek, Barbara M; Mladic, Marija; Bruyneel, Ben; Niessen, Wilfried M A; Honing, Maarten; Somsen, Govert W; Kool, Jeroen

Zietek, Barbara M; Mladic, Marija; Bruyneel, Ben; Niessen, Wilfried M A; Honing, Maarten; Somsen, Govert W; Kool, Jeroen.

Affiliation

Zietek BM; 1 Division of BioAnalytical Chemistry, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Mladic M; 1 Division of BioAnalytical Chemistry, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Bruyneel B; 1 Division of BioAnalytical Chemistry, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Niessen WMA; 1 Division of BioAnalytical Chemistry, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Honing M; 3 hyphen MassSpec, Voorhout, Netherlands.
Somsen GW; 1 Division of BioAnalytical Chemistry, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Kool J; 2 DSM Materials Science Center, Geleen, Netherlands.

SLAS Discov ; 23(3): 283-293, 2018 03.

Article de En | MEDLINE | ID: mdl-29262760

Sujet(s)
Mots clés

ADME; CYPs; drug profiling; drugdrug interactions; nanofractionation

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Cytochrome P-450 CYP1A2 / Antienzymes / Inhibiteurs du cytochrome P-450 CYP1A2 Type d'étude: Diagnostic_studies Limites: Humans Langue: En Journal: SLAS Discov Année: 2018 Type de document: Article Pays d'affiliation: Pays-Bas Pays de publication: États-Unis d'Amérique

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