Shared mechanisms regulate spatiotemporal RhoA-dependent actomyosin contractility during adhesion and cell division.
Small GTPases
; 11(2): 113-121, 2020 03.
Article
de En
| MEDLINE
| ID: mdl-29291271
ABSTRACT
Local modulation of the actin cytoskeleton is essential for the initiation and maintenance of strong homotypic adhesive interfaces between neighboring cells. The epithelial adherens junction (AJ) fulfils a central role in this process by mediating E-cadherin interactions and functioning as a signaling scaffold to control the activity of the small GTPase RhoA and subsequent actomyosin contractility. Interestingly, a number of regulatory proteins that modulate RhoA activity at the AJ also control RhoA during cytokinesis, an actomyosin-dependent process that divides the cytoplasm to generate two daughter cells at the final stages of mitosis. Recent insights have revealed that the central player in AJ stability, p120-catenin (p120), interacts with and modulates essential regulators of actomyosin contraction during cytokinesis. In cancer, loss of this modulation is a common event during tumor progression that can induce chromosomal instability and tumor progression.In this review, we will highlight the functional differences and similarities of the different RhoA-associated factors that have been linked to both the regulation of cell-cell adhesion and cytokinesis.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Actomyosine
/
Adhérence cellulaire
/
Division cellulaire
/
Protéine G RhoA
Limites:
Animals
/
Humans
Langue:
En
Journal:
Small GTPases
Année:
2020
Type de document:
Article
Pays d'affiliation:
Pays-Bas