N-Heterocyclic carbene catalysed redox isomerisation of esters to functionalised benzaldehydes.
Chem Sci
; 6(4): 2366-2370, 2015 Apr 01.
Article
de En
| MEDLINE
| ID: mdl-29308150
ABSTRACT
N-Heterocyclic carbene catalysed redox isomerisation with reduction about the carbonyl has been developed in the transformation of trienyl esters to tetrasubstituted benzaldehydes. The reaction proceeds in good to excellent yield, and in cases that provide 2,2'-biaryls, enantioselectivity is observed. Mechanistic studies demonstrate the intermediacy of a cyclohexenyl ß-lactone, while implicating formation of the homoenolate as turnover limiting.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
Chem Sci
Année:
2015
Type de document:
Article