Calcium channel antagonist binding and pharmacology in rat uterine smooth muscle.
Life Sci
; 37(23): 2187-92, 1985 Dec 09.
Article
de En
| MEDLINE
| ID: mdl-2933568
ABSTRACT
The calcium channel antagonists altered Ca-dependence of high K+-contractions of the estrogen dominant rat myometrium with the following pA2 values PN-200-110, 10.63; nitrendipine, 9.56; nifedipine, 9.41; D-600, 9.05; and diltiazem, 7.57. Specific binding of 3H-nitrendipine occurred to the isolated plasma membrane vesicles with Kd of 0.1 to 0.3 nM and was inhibited by PN-200-110, nitrendipine, nifedipine and D-600, and slightly activated by diltiazem. The binding studies and the contractility studies were in excellent agreement for the three dihydropyridines, but not for D-600 and diltiazem.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Inhibiteurs des canaux calciques
/
Nifédipine
/
Muscles lisses
Limites:
Animals
Langue:
En
Journal:
Life Sci
Année:
1985
Type de document:
Article