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Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter.
Laursen, Louise; Severinsen, Kasper; Kristensen, Kristina Birch; Periole, Xavier; Overby, Malene; Müller, Heidi Kaastrup; Schiøtt, Birgit; Sinning, Steffen.
Affiliation
  • Laursen L; From the Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus University Hospital, Skovagervej 2, DK-8240 Risskov, Denmark and.
  • Severinsen K; From the Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus University Hospital, Skovagervej 2, DK-8240 Risskov, Denmark and.
  • Kristensen KB; From the Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus University Hospital, Skovagervej 2, DK-8240 Risskov, Denmark and.
  • Periole X; the Department of Chemistry and Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Langelandsgade 140, DK-8000 Aarhus C, Denmark.
  • Overby M; From the Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus University Hospital, Skovagervej 2, DK-8240 Risskov, Denmark and.
  • Müller HK; From the Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus University Hospital, Skovagervej 2, DK-8240 Risskov, Denmark and.
  • Schiøtt B; the Department of Chemistry and Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Langelandsgade 140, DK-8000 Aarhus C, Denmark.
  • Sinning S; From the Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus University Hospital, Skovagervej 2, DK-8240 Risskov, Denmark and steffen.sinning@clin.au.dk steffen.sinning@yale.edu.
J Biol Chem ; 293(10): 3510-3523, 2018 03 09.
Article de En | MEDLINE | ID: mdl-29352106
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Modèles moléculaires / Cholestérol / Transporteurs de la sérotonine / Double couche lipidique Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: J Biol Chem Année: 2018 Type de document: Article
Texte intégral
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Modèles moléculaires / Cholestérol / Transporteurs de la sérotonine / Double couche lipidique Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: J Biol Chem Année: 2018 Type de document: Article