Neurosarcoidosis associated with intracerebral haemorrhage: a challenge in diagnosis and management.
Pract Neurol
; 18(3): 246-249, 2018 Jun.
Article
de En
| MEDLINE
| ID: mdl-29363557
ABSTRACT
Sarcoidosis is an idiopathic multisystem granulomatous disorder of unknown cause. Nervous system involvement (central and/or peripheral) is uncommon, developing in 5%-10%. The presenting symptoms are variable, reflecting the level of involvement, and frequently fluctuate and progress. Diagnosing neurosarcoidosis in people with previously confirmed systemic disease may be relatively straightforward, but diagnosing primary neurosarcoidosis is challenging. Managing neurosarcoidosis is primarily consensus based; corticosteroid is its mainstay, alongside corticosteroid-sparing agents and emerging novel therapies. We describe a 39-year-old woman who presented with cranial neuropathy. Serial imaging, cerebrospinal fluid sampling and tissue biopsy gave a diagnosis of probable neurosarcoidosis. Her clinical course was complicated by intracerebral haemorrhage following intravenous corticosteroids for neurological relapse. This is a very rare complication of neurosarcoidosis; we discuss its possible causes and suggest ways to reduce its risk.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Sarcoïdose
/
Maladies du système nerveux central
/
Hémorragie cérébrale
/
Prise en charge de la maladie
Type d'étude:
Diagnostic_studies
/
Risk_factors_studies
Limites:
Adult
/
Female
/
Humans
Langue:
En
Journal:
Pract Neurol
Année:
2018
Type de document:
Article
Pays d'affiliation:
Royaume-Uni