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Neurosarcoidosis associated with intracerebral haemorrhage: a challenge in diagnosis and management.
Maskery, Mark Peter; Cooper, Paul N; Pace, Adrian.
Affiliation
  • Maskery MP; Department of Neurology, Salford Royal NHS Foundation Trust, Salford, UK.
  • Cooper PN; Department of Neurology, Salford Royal NHS Foundation Trust, Salford, UK.
  • Pace A; Department of Neurology, Salford Royal NHS Foundation Trust, Salford, UK.
Pract Neurol ; 18(3): 246-249, 2018 Jun.
Article de En | MEDLINE | ID: mdl-29363557
ABSTRACT
Sarcoidosis is an idiopathic multisystem granulomatous disorder of unknown cause. Nervous system involvement (central and/or peripheral) is uncommon, developing in 5%-10%. The presenting symptoms are variable, reflecting the level of involvement, and frequently fluctuate and progress. Diagnosing neurosarcoidosis in people with previously confirmed systemic disease may be relatively straightforward, but diagnosing primary neurosarcoidosis is challenging. Managing neurosarcoidosis is primarily consensus based; corticosteroid is its mainstay, alongside corticosteroid-sparing agents and emerging novel therapies. We describe a 39-year-old woman who presented with cranial neuropathy. Serial imaging, cerebrospinal fluid sampling and tissue biopsy gave a diagnosis of probable neurosarcoidosis. Her clinical course was complicated by intracerebral haemorrhage following intravenous corticosteroids for neurological relapse. This is a very rare complication of neurosarcoidosis; we discuss its possible causes and suggest ways to reduce its risk.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Sarcoïdose / Maladies du système nerveux central / Hémorragie cérébrale / Prise en charge de la maladie Type d'étude: Diagnostic_studies / Risk_factors_studies Limites: Adult / Female / Humans Langue: En Journal: Pract Neurol Année: 2018 Type de document: Article Pays d'affiliation: Royaume-Uni

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Sarcoïdose / Maladies du système nerveux central / Hémorragie cérébrale / Prise en charge de la maladie Type d'étude: Diagnostic_studies / Risk_factors_studies Limites: Adult / Female / Humans Langue: En Journal: Pract Neurol Année: 2018 Type de document: Article Pays d'affiliation: Royaume-Uni