Your browser doesn't support javascript.
loading
OLT1177, a ß-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Marchetti, Carlo; Swartzwelter, Benjamin; Gamboni, Fabia; Neff, Charles P; Richter, Katrin; Azam, Tania; Carta, Sonia; Tengesdal, Isak; Nemkov, Travis; D'Alessandro, Angelo; Henry, Curtis; Jones, Gerald S; Goodrich, Scott A; St Laurent, Joseph P; Jones, Terry M; Scribner, Curtis L; Barrow, Robert B; Altman, Roy D; Skouras, Damaris B; Gattorno, Marco; Grau, Veronika; Janciauskiene, Sabina; Rubartelli, Anna; Joosten, Leo A B; Dinarello, Charles A.
Affiliation
  • Marchetti C; Department of Medicine, University of Colorado Denver, Aurora, CO 80045.
  • Swartzwelter B; Department of Medicine, University of Colorado Denver, Aurora, CO 80045.
  • Gamboni F; Department of Medicine, University of Colorado Denver, Aurora, CO 80045.
  • Neff CP; Department of Medicine, University of Colorado Denver, Aurora, CO 80045.
  • Richter K; Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, German Centre for Lung Research, Justus-Liebig-University Giessen, 35390 Giessen, Germany.
  • Azam T; Department of Medicine, University of Colorado Denver, Aurora, CO 80045.
  • Carta S; Cell Biology Unit, Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria "San Martino"-Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy.
  • Tengesdal I; Department of Medicine, University of Colorado Denver, Aurora, CO 80045.
  • Nemkov T; Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, CO 80045.
  • D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, CO 80045.
  • Henry C; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30307.
  • Jones GS; Chemic Laboratories, Inc., Canton, MA 02021.
  • Goodrich SA; Chemic Laboratories, Inc., Canton, MA 02021.
  • St Laurent JP; Chemic Laboratories, Inc., Canton, MA 02021.
  • Jones TM; J&S Studies, Inc., College Station, TX 77845.
  • Scribner CL; Olatec Therapeutics LLC, New York, NY 10065.
  • Barrow RB; Olatec Therapeutics LLC, New York, NY 10065.
  • Altman RD; Department of Rheumatology, University of California, Los Angeles, CA 90404.
  • Skouras DB; Olatec Therapeutics LLC, New York, NY 10065.
  • Gattorno M; Unita' Operativa Complessa Pediatria 2, G. Gaslini Institute, 16100 Genova, Italy.
  • Grau V; Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, German Centre for Lung Research, Justus-Liebig-University Giessen, 35390 Giessen, Germany.
  • Janciauskiene S; Department of Respiratory Medicine, German Center for Lung Research, Hannover Medical School, 30625 Hannover, Germany.
  • Rubartelli A; Cell Biology Unit, Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria "San Martino"-Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy.
  • Joosten LAB; Department of Medicine, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
  • Dinarello CA; Department of Medicine, University of Colorado Denver, Aurora, CO 80045; cdinare333@aol.com.
Proc Natl Acad Sci U S A ; 115(7): E1530-E1539, 2018 02 13.
Article de En | MEDLINE | ID: mdl-29378952
Sujet(s)
Mots clés
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Inflammasomes / Protéine-3 de la famille des NLR contenant un domaine pyrine / Inflammation / Macrophages / Anti-inflammatoires / Nitriles Type d'étude: Health_economic_evaluation Limites: Animals / Humans / Male Langue: En Journal: Proc Natl Acad Sci U S A Année: 2018 Type de document: Article Pays de publication: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Inflammasomes / Protéine-3 de la famille des NLR contenant un domaine pyrine / Inflammation / Macrophages / Anti-inflammatoires / Nitriles Type d'étude: Health_economic_evaluation Limites: Animals / Humans / Male Langue: En Journal: Proc Natl Acad Sci U S A Année: 2018 Type de document: Article Pays de publication: États-Unis d'Amérique