A tri-serine cluster within the topoisomerase II&#945;-interaction domain of the BLM helicase is required for regulating chromosome breakage in human cells.

Behnfeldt, Julia Harris; Acharya, Samir; Tangeman, Larissa; Gocha, April Sandy; Keirsey, Jeremy; Groden, Joanna

A tri-serine cluster within the topoisomerase IIα-interaction domain of the BLM helicase is required for regulating chromosome breakage in human cells.

Behnfeldt, Julia Harris; Acharya, Samir; Tangeman, Larissa; Gocha, April Sandy; Keirsey, Jeremy; Groden, Joanna.

Affiliation

Behnfeldt JH; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Acharya S; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Tangeman L; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Gocha AS; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Keirsey J; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Groden J; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.

Hum Mol Genet ; 27(7): 1241-1251, 2018 04 01.

Article de En | MEDLINE | ID: mdl-29385443

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: ADN topoisomérases de type II / Cassure de chromosome / Instabilité des chromosomes / RecQ helicases / Protéines liant le poly-adp-ribose Limites: Humans Langue: En Journal: Hum Mol Genet Sujet du journal: BIOLOGIA MOLECULAR / GENETICA MEDICA Année: 2018 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Royaume-Uni

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