Docetaxel prodrug self-assembled nanosystem: Synthesis, formulation and cytotoxicity.
Bioorg Med Chem Lett
; 28(4): 826-830, 2018 02 15.
Article
de En
| MEDLINE
| ID: mdl-29395972
ABSTRACT
Conventional drug delivery systems of docetaxel (DTX) are challenged with low drug loading efficiency and potential carriers-induced toxicity. In this work, a docetaxel prodrug self-assembled nanosystem was designed and synthesized by conjugating docetaxel with oleic acid (OA) exploring a thioether as the linker, which is redox-sensitive to the redox environment within tumor cells. Notably, the carrier-free nanomedicine which does not need any carrier has obviously high drug loading that reaches 58%. Moreover, the cytotoxicity of DTX-S-OA maintains an equal level with DTX. The novel prodrug conjugate therefore has a promising perspective as carrier-free nanomedicine for cancer therapy due to its high drug loading property, redox-sensitive release and long circulation mechanism.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Vecteurs de médicaments
/
Promédicaments
/
Taxoïdes
/
Nanoparticules
/
Antinéoplasiques
Limites:
Humans
Langue:
En
Journal:
Bioorg Med Chem Lett
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2018
Type de document:
Article
Pays d'affiliation:
Chine