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Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.
Degorce, Sébastien L; Anjum, Rana; Dillman, Keith S; Drew, Lisa; Groombridge, Sam D; Halsall, Christopher T; Lenz, Eva M; Lindsay, Nicola A; Mayo, Michele F; Pink, Jennifer H; Robb, Graeme R; Scott, James S; Stokes, Stephen; Xue, Yafeng.
Affiliation
  • Degorce SL; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom. Electronic address: sebastien.degorce@astrazeneca.com.
  • Anjum R; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Dillman KS; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Drew L; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Groombridge SD; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.
  • Halsall CT; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.
  • Lenz EM; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Lindsay NA; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Mayo MF; Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Boston, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Pink JH; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.
  • Robb GR; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Scott JS; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Stokes S; Medicinal Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Xue Y; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg SE-431 83, Mölndal, Sweden.
Bioorg Med Chem ; 26(4): 913-924, 2018 02 15.
Article de En | MEDLINE | ID: mdl-29398441
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrroles / Thiazines / Interleukin-1 Receptor-Associated Kinases Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Bioorg Med Chem Sujet du journal: BIOQUIMICA / QUIMICA Année: 2018 Type de document: Article Pays de publication: Royaume-Uni
Texte intégral
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Imprimer
XML
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrroles / Thiazines / Interleukin-1 Receptor-Associated Kinases Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Bioorg Med Chem Sujet du journal: BIOQUIMICA / QUIMICA Année: 2018 Type de document: Article Pays de publication: Royaume-Uni