Potential Uses of Isolated Toxin Peptides in Neuropathic Pain Relief: A Literature Review.
World Neurosurg
; 113: 333-347.e5, 2018 May.
Article
de En
| MEDLINE
| ID: mdl-29421449
ABSTRACT
Neuropathic pain is a subset of chronic pain that is caused by neurons that are damaged or firing aberrantly in the peripheral or central nervous systems. The treatment guidelines for neuropathic pain include antidepressants, calcium channel α2 delta ligands, topical therapy, and opioids as a second-line option. Pharmacotherapy has not been effective in the treatment of neuropathic pain except in the treatment of trigeminal neuralgia with carbamazepine. The inability to properly treat neuropathic pain causes frustration in both the patients and their treating physicians. Venoms, which are classically believed to be causes of pain and death, have peptide components that have been implicated in pain relief. Although some venoms are efficacious and have shown benefits in patients, their side-effect profile precludes their more widespread use. This review identifies and explores the use of venoms in neuropathic pain relief. This treatment can open doors to potential therapeutic targets. We believe that further research into the mechanisms of action of these receptors as well as their functions in nature will provide alternative therapies as well as a window into how they affect neuropathic pain.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Peptides
/
Toxines biologiques
/
Venins
/
Analgésiques non narcotiques
/
Névralgie
Type d'étude:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
World Neurosurg
Sujet du journal:
NEUROCIRURGIA
Année:
2018
Type de document:
Article