Exosomal microRNAs (exomiRs): Small molecules with a big role in cancer.
Cancer Lett
; 420: 228-235, 2018 04 28.
Article
de En
| MEDLINE
| ID: mdl-29425686
ABSTRACT
Exosomes are secreted vesicles which can transmit molecular cargo between cells. Exosomal microRNAs (exomiRs) have drawn much attention in recent years because there is increasing evidence to suggest that loading of microRNAs into exosomes is not a random process. Preclinical studies have identified functional roles for exomiRs in influencing many hallmarks of cancer. Mechanisms underpinning their actions, such as exomiR receptors ("miRceptors"), are now becoming apparent. Even more exciting is the fact that exomiRs are highly suitable candidates for use as non-invasive biomarkers in an era of personalized cancer medicine.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
MicroARN
/
Exosomes
/
Tumeurs
Limites:
Humans
Langue:
En
Journal:
Cancer Lett
Année:
2018
Type de document:
Article
Pays d'affiliation:
Royaume-Uni