Modulation of incisor eruption in rats by sympathetic efferents.
Arch Oral Biol
; 89: 31-36, 2018 May.
Article
de En
| MEDLINE
| ID: mdl-29432940
ABSTRACT
INTRODUCTION:
Intact neural supply is necessary for tooth eruption. Sympathetic denervation accelerates or decelerates the eruption rate depending on the tooth condition (intact or injured). The aim of this study is to reexamine the role of the sympathetic innervation, through the observation of the effects of pre or post ganglionic chemical sympathectomy on the eruption of intact rat incisors. MATERIALS ANDMETHODS:
Different groups of rats were subjected to either ganglionic or peripheral chemical sympathectomy and the observed effects on incisor eruption were compared to those made on intact/sham groups or on rats subjected to inferior alveolar nerve (IAN) lesion.RESULTS:
The total amount of eruption in control/naïve rats, measured over a total period of 144â¯h, was 3⯱â¯0.15â¯mm and decreased to 2.57⯱â¯0.06â¯mm (nâ¯=â¯8; pâ¯<â¯0.01) or 2.8⯱â¯0.10â¯mm (nâ¯=â¯8; pâ¯<â¯0.05) following treatment with guanethidine and hexamethonium, respectively. This amount decreased to 1.8⯱â¯0.14â¯mm (pâ¯<â¯0.001 vs. control, nâ¯=â¯7; or pâ¯<â¯0.01 vs. sham, nâ¯=â¯5) in rats subjected to IAN lesion.CONCLUSION:
Sympathectomy delayed tooth eruption. Blocking the sympathetic effectors with guanethidine exerted more potent effects than ganglionic block with hexamethonium. Intact sympathetic supply is required for tooth growth under normal conditions.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Système nerveux sympathique
/
Éruption dentaire
/
Incisive
/
Mandibule
/
Nerf mandibulaire
Limites:
Animals
Langue:
En
Journal:
Arch Oral Biol
Année:
2018
Type de document:
Article