Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.
Nat Commun
; 9(1): 711, 2018 02 19.
Article
de En
| MEDLINE
| ID: mdl-29459775
ABSTRACT
Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks that allow causal inference. Here, we discuss the characteristics of Recall-by-Genotype (RbG) as a study design aimed at addressing both these needs. We describe two broad scenarios for the application of RbG studies using single variants and those using multiple variants. We consider the efficacy and practicality of the RbG approach, provide a catalogue of UK-based resources for such studies and present an online RbG study planner.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Phénotype
/
Étude d'association pangénomique
/
Génotype
Type d'étude:
Etiology_studies
/
Risk_factors_studies
Limites:
Humans
Pays/Région comme sujet:
Europa
Langue:
En
Journal:
Nat Commun
Sujet du journal:
BIOLOGIA
/
CIENCIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
Royaume-Uni