Stachybotrychromenes A-C: novel cytotoxic meroterpenoids from Stachybotrys sp.
Mycotoxin Res
; 34(3): 179-185, 2018 Aug.
Article
de En
| MEDLINE
| ID: mdl-29549547
ABSTRACT
In the course of gaining new insights into the secondary metabolite profile of various Stachybotrys strains, in particular concerning triprenyl phenol-like compounds, so far, unknown metabolites with analogous structural features were discovered. Three novel meroterpenoids containing a chromene ring moiety, namely stachybotrychromenes A-C, were isolated from solid culture of the filamentous fungus Stachybotrys chartarum DSMZ 12880 (chemotype S). Their structures were elucidated by means of comprehensive spectroscopic analysis (1D and 2D NMR, ESI-HRMS, and CD) as well as by comparison with spectroscopic data of structural analogues described in literature. Stachybotrychromenes A and B exhibited moderate cytotoxic effects on HepG2 cells after 24 h with corresponding IC50 values of 73.7 and 28.2 µM, respectively. Stachybotrychromene C showed no significant cytotoxic activity up to 100 µM. Moreover, it is noteworthy that stachybotrychromenes A-C are produced not only by S. chartarum chemotype S but also S. chartarum chemotype A and Stachybotrys chlorohalonata.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Stachybotrys
/
Terpènes
/
Mycotoxines
Limites:
Humans
Langue:
En
Journal:
Mycotoxin Res
Année:
2018
Type de document:
Article
Pays d'affiliation:
Allemagne