Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 2: Prediction of Decreased Substrate Exposure After Rifabutin or Carbamazepine.

Lutz, Justin D; Kirby, Brian J; Wang, Lu; Song, Qinghua; Ling, John; Massetto, Benedetta; Worth, Angela; Kearney, Brian P; Mathias, Anita

Lutz, Justin D; Kirby, Brian J; Wang, Lu; Song, Qinghua; Ling, John; Massetto, Benedetta; Worth, Angela; Kearney, Brian P; Mathias, Anita.

Affiliation

Lutz JD; Department of Clinical Pharmacology, Gilead Sciences, Inc., Foster City, California, USA.
Kirby BJ; Department of Clinical Pharmacology, Gilead Sciences, Inc., Foster City, California, USA.
Wang L; Department of Biometrics, Gilead Sciences, Inc., Foster City, California, USA.
Song Q; Department of Biometrics, Gilead Sciences, Inc., Foster City, California, USA.
Ling J; Department of Clinical Pharmacology, Gilead Sciences, Inc., Foster City, California, USA.
Massetto B; Department of Clinical Operations, Gilead Sciences, Inc., Foster City, California, USA.
Worth A; Department of Clinical Research, Gilead Sciences, Inc., Foster City, California, USA.
Kearney BP; Department of Clinical Pharmacology, Gilead Sciences, Inc., Foster City, California, USA.
Mathias A; Department of Clinical Pharmacology, Gilead Sciences, Inc., Foster City, California, USA.

Clin Pharmacol Ther ; 104(6): 1191-1198, 2018 12.

Article de En | MEDLINE | ID: mdl-29569712

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Rifampicine / Carbamazépine / Rifabutine / Glycoprotéine P / Cytochrome P-450 CYP3A / Modulateurs du transport transmembranaire / Inducteurs des enzymes du cytochrome P-450 / Récepteur du prégnane X Type d'étude: Etiology_studies / Prognostic_studies / Risk_factors_studies Limites: Adolescent / Adult / Female / Humans / Male / Middle aged Langue: En Journal: Clin Pharmacol Ther Année: 2018 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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