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N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration.
Chen, Chia-Yi; Melo, Esther; Jakob, Peter; Friedlein, Arno; Elsässer, Brigitta; Goettig, Peter; Kueppers, Verena; Delobel, Frederic; Stucki, Corinne; Dunkley, Tom; Fauser, Sascha; Schilling, Oliver; Iacone, Roberto.
Affiliation
  • Chen CY; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Melo E; Roche Pharma Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Jakob P; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Friedlein A; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Elsässer B; Division of Structural Biology, Department of Biosciences, University of Salzburg, Billrothstrasse 11, 5020 Salzburg, Austria.
  • Goettig P; Division of Structural Biology, Department of Biosciences, University of Salzburg, Billrothstrasse 11, 5020 Salzburg, Austria.
  • Kueppers V; Roche Pharma Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Delobel F; Roche Pharma Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Stucki C; Roche Pharma Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Dunkley T; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Fauser S; Roche Pharma Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
  • Schilling O; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany; BIOSS Centre for Biological Signaling Studies, University of Freiburg, 79104 Freiburg, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelber
  • Iacone R; Roche Pharma Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.
Matrix Biol ; 70: 84-101, 2018 09.
Article de En | MEDLINE | ID: mdl-29572155
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Fragments peptidiques / Pigments rétiniens / Thrombospondine-1 / Agents angiogéniques / High-temperature requirement A serine peptidase 1 / Dégénérescence maculaire Type d'étude: Prognostic_studies Limites: Aged / Humans Langue: En Journal: Matrix Biol Sujet du journal: BIOLOGIA MOLECULAR / BIOQUIMICA Année: 2018 Type de document: Article Pays d'affiliation: Allemagne Pays de publication: Pays-Bas
Texte intégral
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Imprimer
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Fragments peptidiques / Pigments rétiniens / Thrombospondine-1 / Agents angiogéniques / High-temperature requirement A serine peptidase 1 / Dégénérescence maculaire Type d'étude: Prognostic_studies Limites: Aged / Humans Langue: En Journal: Matrix Biol Sujet du journal: BIOLOGIA MOLECULAR / BIOQUIMICA Année: 2018 Type de document: Article Pays d'affiliation: Allemagne Pays de publication: Pays-Bas