Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections.
Nat Commun
; 9(1): 1381, 2018 04 11.
Article
de En
| MEDLINE
| ID: mdl-29643376
ABSTRACT
Host immunity exerts strong selective pressure on pathogens. Population-level genetic analysis can identify signatures of this selection, but these signatures reflect the net selective effect of all hosts and vectors in a population. In contrast, analysis of pathogen diversity within hosts provides information on individual, host-specific selection pressures. Here, we combine these complementary approaches in an analysis of the malaria parasite Plasmodium falciparum using haplotype sequences from thousands of natural infections in sub-Saharan Africa. We find that parasite genotypes show preferential clustering within multi-strain infections in young children, and identify individual amino acid positions that may contribute to strain-specific immunity. Our results demonstrate that natural host defenses to P. falciparum act in an allele-specific manner to block specific parasite haplotypes from establishing blood-stage infections. This selection partially explains the extreme amino acid diversity of many parasite antigens and suggests that vaccines targeting such proteins should account for allele-specific immunity.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Plasmodium falciparum
/
Haplotypes
/
Paludisme à Plasmodium falciparum
/
Interactions hôte-parasite
/
Antigènes de protozoaire
Limites:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Pays/Région comme sujet:
Africa
Langue:
En
Journal:
Nat Commun
Sujet du journal:
BIOLOGIA
/
CIENCIA
Année:
2018
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique