Are endometrial cancer radiotherapy results age related?
Clin Transl Oncol
; 20(11): 1416-1421, 2018 Nov.
Article
de En
| MEDLINE
| ID: mdl-29651671
ABSTRACT
OBJECTIVE:
To analyze the impact of age on radiotherapy results based on cancer-specific survival (CSS), vaginal-cuff relapses (VCR) and complications analysis in 438 patients with endometrial carcinoma (EC) receiving postoperative radiotherapy (PRT) divided into three age groups for analysis. MATERIALS ANDMETHODS:
From 2003 to 2015, 438 patients with EC were treated with PRT and divided into three age groups Group-1 202 patients < 65 years; Group-2 210 patients ≥ 65 and < 80 years; Group-3 26 patients ≥ 80 years. Vaginal toxicity was assessed using the objective LENT-SOMA criteria and RTOG scores were recorded for the rectum, bladder, and small bowel. STATISTICS Chi square and Student's t tests, Kaplan-Meier survival study for analysis of CSS.RESULTS:
The mean follow-up was 5.6 years in Group-1, 5.6 years in Group-2 and 6.3 years in Group-3 (p = 0.38). No differences were found among the groups in distribution of stage, grade, myometrial invasion, Type 1 vs. 2 EC and VLSI (p = 0.97, p = 0.52, p = 0.35, p = 0.48, p = 0.76, respectively). There were no differences in rectal, bladder and vagina late toxicity (p = 0.46, p = 0.17, p = 0.75, respectively). A better CSS at 5 years was found in Group-1 (p = 0.006), and significant differences were found in late severe small bowel toxicity in Group-3 (p = 0.005). VCR was increased in Group-3 (p = 0.017).CONCLUSIONS:
Patients ≥ 65 years had a worse outcome in comparison to younger patients. Late vaginal, rectal and bladder toxicities were similar in the three groups, although an increase of severe late small bowel toxicity led to IMRT in patients ≥ 80 years. Further larger studies are needed including quality of life analysis in patients ≥ 80 years.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Vieillissement
/
Tumeurs de l'endomètre
/
Carcinome endométrioïde
Type d'étude:
Observational_studies
/
Risk_factors_studies
Aspects:
Patient_preference
Limites:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Langue:
En
Journal:
Clin Transl Oncol
Année:
2018
Type de document:
Article
Pays d'affiliation:
Espagne