Human Placental Growth Hormone Variant in Pathological Pregnancies.
Endocrinology
; 159(5): 2186-2198, 2018 05 01.
Article
de En
| MEDLINE
| ID: mdl-29659791
ABSTRACT
Growth hormone (GH), an endocrine hormone, primarily secreted from the anterior pituitary, stimulates growth, cell reproduction, and regeneration and is a major regulator of postnatal growth. Humans have two GH genes that encode two versions of GH proteins a pituitary version (GH-N/GH1) and a placental GH-variant (GH-V/GH2), which are expressed in the syncytiotrophoblast and extravillous trophoblast cells of the placenta. During pregnancy, GH-V replaces GH-N in the maternal circulation at mid-late gestation as the major circulating form of GH. This remarkable change in spatial and temporal GH secretion patterns is proposed to play a role in mediating maternal adaptations to pregnancy. GH-V is associated with fetal growth, and its circulating concentrations have been investigated across a range of pregnancy complications. However, progress in this area has been hindered by a lack of readily accessible and reliable assays for measurement of GH-V. This review will discuss the potential roles of GH-V in normal and pathological pregnancies and will touch on the assays used to quantify this hormone.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Hormones placentaires
/
Complications de la grossesse
/
Hormone de croissance
Limites:
Female
/
Humans
/
Pregnancy
Langue:
En
Journal:
Endocrinology
Année:
2018
Type de document:
Article
Pays d'affiliation:
Nouvelle-Zélande