Your browser doesn't support javascript.
loading
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.
Nchinda, Aloysius T; Le Manach, Claire; Paquet, Tanya; Gonzàlez Cabrera, Diego; Wicht, Kathryn J; Brunschwig, Christel; Njoroge, Mathew; Abay, Efrem; Taylor, Dale; Lawrence, Nina; Wittlin, Sergio; Jiménez-Díaz, María-Belén; Santos Martínez, María; Ferrer, Santiago; Angulo-Barturen, Iñigo; Lafuente-Monasterio, Maria Jose; Duffy, James; Burrows, Jeremy; Street, Leslie J; Chibale, Kelly.
Affiliation
  • Nchinda AT; Drug Discovery and Development Center (H3D), Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Le Manach C; Drug Discovery and Development Center (H3D), Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Paquet T; Drug Discovery and Development Center (H3D), Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Gonzàlez Cabrera D; Drug Discovery and Development Center (H3D), Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Wicht KJ; Drug Discovery and Development Center (H3D), Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
  • Brunschwig C; Drug Discovery and Development Center (H3D), Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Observatory, Cape Town 7925 , South Africa.
  • Njoroge M; Drug Discovery and Development Center (H3D), Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Observatory, Cape Town 7925 , South Africa.
  • Abay E; Drug Discovery and Development Center (H3D), Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Observatory, Cape Town 7925 , South Africa.
  • Taylor D; Drug Discovery and Development Center (H3D), Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Observatory, Cape Town 7925 , South Africa.
  • Lawrence N; Drug Discovery and Development Center (H3D), Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Observatory, Cape Town 7925 , South Africa.
  • Wittlin S; Swiss Tropical and Public Health Institute , Socinstrasse 57 , 4002 Basel , Switzerland.
  • Jiménez-Díaz MB; University of Basel , 4003 Basel , Switzerland.
  • Santos Martínez M; GlaxoSmithKline, Tres Cantos Medicines Development Campus , Severo Ochoa, 2 , 28760 Tres Cantos, Madrid , Spain.
  • Ferrer S; GlaxoSmithKline, Tres Cantos Medicines Development Campus , Severo Ochoa, 2 , 28760 Tres Cantos, Madrid , Spain.
  • Angulo-Barturen I; GlaxoSmithKline, Tres Cantos Medicines Development Campus , Severo Ochoa, 2 , 28760 Tres Cantos, Madrid , Spain.
  • Lafuente-Monasterio MJ; GlaxoSmithKline, Tres Cantos Medicines Development Campus , Severo Ochoa, 2 , 28760 Tres Cantos, Madrid , Spain.
  • Duffy J; GlaxoSmithKline, Tres Cantos Medicines Development Campus , Severo Ochoa, 2 , 28760 Tres Cantos, Madrid , Spain.
  • Burrows J; Medicines for Malaria Venture, ICC , Route de Pré-Bois 20 , PO Box 1826, 1215 Geneva , Switzerland.
  • Street LJ; Medicines for Malaria Venture, ICC , Route de Pré-Bois 20 , PO Box 1826, 1215 Geneva , Switzerland.
  • Chibale K; Drug Discovery and Development Center (H3D), Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
J Med Chem ; 61(9): 4213-4227, 2018 05 10.
Article de En | MEDLINE | ID: mdl-29665687
Sujet(s)
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Plasmodium falciparum / Pyridines / Découverte de médicament / Imidazoles / Paludisme Type d'étude: Diagnostic_studies Limites: Animals / Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2018 Type de document: Article Pays d'affiliation: République d'Afrique du Sud
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Plasmodium falciparum / Pyridines / Découverte de médicament / Imidazoles / Paludisme Type d'étude: Diagnostic_studies Limites: Animals / Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2018 Type de document: Article Pays d'affiliation: République d'Afrique du Sud