D-dimer from central and peripheral blood samples in asymptomatic central venous catheter-related thrombosis in patients with cancer.
Phlebology
; 34(1): 52-57, 2019 Feb.
Article
de En
| MEDLINE
| ID: mdl-29690838
ABSTRACT
OBJECTIVES:
To evaluate the usefulness of a negative D-dimer in peripheral or central venous blood to screen for asymptomatic catheter-related thrombosis in cancer patients.METHODS:
D-dimer was measured in blood from central venous catheter and peripheral venous samples in 48 patients with cancer. Asymptomatic catheter-related thrombosis was identified via Doppler ultrasound. Bland and Altman's limits of agreement analysis was used to compare sample sites. Sensitivity and specificity of D-dimer was calculated.RESULTS:
Overall, 33 of the central samples and 32 of the peripheral samples had D-dimer levels below the cutoff (≥0.3 mg/l). Mean central D-dimer was 0.31 ± 0.35 mg/l; peripheral 0.24 ± 0.22 mg/l (p = 0.5). Bland-Altman plot showed that the two sample sites were not equivalent. Catheter-related thrombosis was demonstrated in five patients, and there were three false negatives. Peripheral D-dimer had a negative predictive value of 90.9%.CONCLUSIONS:
A negative D-dimer may be useful for screening asymptomatic catheter-related thrombosis in patients with cancer, but the central and peripheral sample sites are not equivalent.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Thrombose
/
Produits de dégradation de la fibrine et du fibrinogène
/
Échographie-doppler
/
Cathéters
/
Tumeurs
Type d'étude:
Etiology_studies
Limites:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Phlebology
Sujet du journal:
ANGIOLOGIA
Année:
2019
Type de document:
Article
Pays d'affiliation:
Mexique